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In-fact, between the ages of 21-36, smoking more than 10-15 cigarettes per day is linked with a reduction in leg muscle strength of around 2.5-5% (21)

CS-induced oxidative stress is responsible for altered cellular metabolism, including increased infiltrating immune cells, pro-inflammatory cytokine production, proteaseantiprotease imbalance, lipid peroxidation, apoptosis, upregulation of unfolded protein response (UPR), and protein misfolding

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Therefore, it can be suggested that adding motivating messages and advices for smoking cessation on the cigarette packs together with the pictorial warnings could be more effective than presenting the graphical warnings only

[38] Moreover, advertising has a limited effect on influencing smoking behavior